Pharmacology of Risperidone – therapeutic applications/ effects

Therapeutic applications

The primary indication of risperidone is in schizophrenia treatment though it is used in other psychoses. For schizophrenia, risperidone is indicated for acute and maintenance treatment in adults and also for treatment in 13-17 year-old adolescents. (6,14). Apart from schizophrenia, risperidone is employed for short-term treatment of bipolar mania conditions in adults, children and 10-17 year-old adolescents; either as a monotheraphy or a combination therapy with lithium or valproate. (6,14). A final indication of risperidone is in treating autism associated irritability in 5-16 year old children and adolescents. (6,14).

Outcomes and benefits of treatment

Risperidone treatment is associated with various beneficial effects noted with SGAs. One of these is that it has lower tendency to cause EPSEs compared to first generation antipsychotics. (1-5, 11-15). Risperidone does also not exhibit toxic effects associated with Clozapine, a SGA that has been shown to have a larger size antipsychotic effects (1, 5, 7, 11). Long-acting risperidone is also suggested to have enhanced tolerance profiles and improves compliance hence helps in combating psychoses in the long term (10-13).

Associated therapeutic approaches

Risperidone is mainly used as a monotherapy drug in treatment of psychoses such as schizophrenia. (5,7). For acute maniacor bipolar I disorder- associated mixed episodes, a combination therapy of risperidone with lithium or valproate is employed. (5,7).

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